Within a week, she complained of a recurrence of her Babesia symptoms, and I instructed her to go back on Mepron but at half dose. If patients are having symptoms, it is necessary to determine if symptoms are related to Herxheimer reactions, drug side effects, or under-treatment due to tapering their antimicrobials too quickly.įor example, I advised a patient with Lyme disease and babesiosis to stop her Mepron when she reached a dose of 62.5 mg daily. Therefore, I taper the antimicrobials as I increase the dose of disulfiram. If they stay on these, the Herxheimer reactions are more severe. Most of my patients are already on antimicrobials when they begin disulfiram. I advise my patients to never advance the dosage if they are still Herxing, and to check in with me by email every two weeks. If the Herxheimer reaction is severe or prolonged, then the dose of disulfiram should be decreased. Splitting the dose of disulfiram to two or three times daily and taking it with vitamin C and zinc also may mitigate Herxheimer reactions as well as neurotoxicity. Alpha-lipoic acid (ALA), curcumin, fish oil, boswellia and CBD will decrease brain inflammation.ĭihydromyricetin facilitates metabolism of both alcohol and acetaldehyde, (5) and some patients report that it also helps with the die-off symptoms.
Vitamin C, nicotinamide, selenium and N-acetyl cysteine (NAC) will help prevent Herx reactions. Herxheimer reactions should be treated with the usual binders, anti-inflammations, Burbur-Pinella, epsom salt/baking soda baths, Tri-salts, glutathione, detox and other drainage remedies. Patients continue the target dose for two to three months, and then stop. The maintenance or target dose is based on weight but also tolerance: 500 mg daily for patients over 180 lbs., 375 mg daily for patients 140-180 lbs., and 250 mg for patients 100-140 lbs. Patients increase the dose every two weeks based on tolerance. The medication is then released in the small intestine, which is best in this situation. Enteric coating allows the medications to get through the stomach without being broken down by the stomach acid. Patients who appear fragile, inflamed, or poor detoxifiers start as low as 15 -25 mg every week, which is available at compounding pharmacies.ĭoctors prescribing these doses should request that capsules be enteric-coated and time-release.
To mitigate these reactions, I suggest starting with low doses, 62.5 mg or 125 mg every three days. The biggest issue is still Herxheimer reactions. (3)īecause we have large groups of patients on disulfiram reporting their experience on dedicated Facebook groups, we are getting a lot of feedback. He took disulfiram for four months and has now been off all treatment for almost two and a half years, feeling better than ever. Liegner’s first patient had been on triple antibiotic treatment for eight years for Lyme disease and babesiosis, and could not stop his treatment regimen without suffering a relapse. He is seeing sustained remissions of six months or more after completing treatment in many patients.ĭr. Kenneth Liegner has had the longest experience treating tick-borne infections with disulfiram. Sustained remissions in many Lyme patientsĭr.
My patients now get it through Canadian pharmacies where it is sourced from other countries. Ninety of my patients are now on disulfiram, and, judging from the posts on Facebook, there are many more now taking this drug.īecause of the increase in demand and the fact that Teva has stopped producing it, most U.S. I can now say definitively that disulfiram is indeed a breakthrough in the treatment of Lyme disease and babesiosis. In a previous blog about disulfiram, in July, 2019, (1) I reported on preliminary data, both in vivo and in vitro, suggesting that disulfiram may be a good drug to treat Lyme disease and babesiosis.
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